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Related Concept Videos

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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

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Osteoclasts in Bone Remodeling

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Related Experiment Video

Updated: Jun 8, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Glucocorticosteroid-induced Osteonecrosis:lessons For the Dermatologist(CME).

D Indira1, S Snehal, C R Sudha

  • 1Department of Dermatology, Gandhi Hospital/ Gandhi Medical College, Scunderabad - 500 003, India.

Indian Journal of Dermatology, Venereology and Leprology
|September 30, 2010
PubMed
Summary

Glucocorticosteroid therapy may cause osteonecrosis (avascular necrosis), a serious complication. Early diagnosis and prevention are crucial for dermatologists to manage this debilitating condition.

Related Experiment Videos

Last Updated: Jun 8, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Area of Science:

  • Dermatology
  • Orthopedics
  • Endocrinology

Background:

  • Glucocorticosteroids are widely used but can cause osteonecrosis (avascular necrosis).
  • Dermatologists may be unaware of this serious steroid-related complication.
  • The exact mechanisms and prevalence in dermatology are not fully understood.

Purpose of the Study:

  • To review current understanding of osteonecrosis pathogenesis.
  • To identify risk factors, diagnostic methods, and treatments.
  • To provide guidelines for dermatologists to prevent this complication.

Main Methods:

  • Literature review of pathogenesis, risk factors, diagnosis, and treatment.
  • Formulation of clinical guidelines for dermatologists.

Main Results:

  • Osteonecrosis is a significant, though perhaps under-recognized, complication of glucocorticosteroid therapy.
  • Early diagnosis and intervention can reduce morbidity.
  • Specific risk factors and preventive strategies exist.

Conclusions:

  • Dermatologists need increased awareness of glucocorticosteroid-induced osteonecrosis.
  • Guidelines are proposed for early detection and prevention.
  • Further research into pathogenesis and prevalence is warranted.