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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Lichen Planus-a Clinico-histopathological.

V K Garg¹, A Nangia, K Logani

¹Department of Dermatology & STD and Department of Pathology Lady Hardinge Medical College & Associated S.K. & K.S. C. Hospitals, New Delhi-110 001, India.

Indian Journal of Dermatology, Venereology and Leprology

|September 30, 2010

Summary

This study analyzed 75 lichen planus patients, finding a female predominance and common papular lesions on lower limbs. Clinico-histopathological discrepancies were noted in some cases.

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Area of Science:

Dermatology
Histopathology

Background:

Lichen planus is a common inflammatory condition affecting skin and mucous membranes.
Understanding its clinico-histopathological features is crucial for accurate diagnosis and management.

Purpose of the Study:

To investigate the clinico-histopathological characteristics of lichen planus in a cohort of 75 patients.
To identify demographic, clinical, and histopathological patterns associated with lichen planus.

Main Methods:

Retrospective analysis of 75 patients diagnosed with lichen planus.
Evaluation of clinical presentations, including lesion type, distribution, and associated symptoms.
Histopathological examination of skin biopsies to correlate with clinical findings.

Main Results:

A significant female predominance (1:13 male to female ratio) was observed, with the 31-40 year age group most affected.
Severe itching was a primary symptom in all patients, with papular lesions (72%) and lower limb involvement (38%) being most common.
Mucosal (24%) and nail (17.3%) involvement occurred, while lichen planopilaris and oral lichen planus were infrequent. Clinico-histopathological discrepancies were seen in 7 patients, and Civatte bodies were present in only 37%.

Conclusions:

Lichen planus exhibits distinct demographic and clinical features, with a notable female predilection and specific lesion patterns.
Histopathological findings, including the presence of Civatte bodies, may not always align with clinical presentation, highlighting the importance of integrated diagnosis.
Further research is warranted to explore the underlying mechanisms and optimize treatment strategies for lichen planus.