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Pityriasis rosea: A histopathologic study.

D Prasad¹, R R Mittal, R Walia

¹Department of Dermato-Venereology and Pathology, Government Medical College, Patiala, India.

Indian Journal of Dermatology, Venereology and Leprology

|September 30, 2010

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Pityriasis rosea (PR) histopathology shows distinct features from dermatitis, including epidermal changes and red blood cell extravasation. Herald patches share similarities with secondary lesions, with minor variations observed.

Area of Science:

Dermatopathology
Histology
Dermatology

Background:

Pityriasis rosea (PR) histopathology is often compared to dermatitis.
Histological differences between PR and dermatitis are expected.
Previous studies have described characteristic PR features.

Purpose of the Study:

To detail the histopathologic features of pityriasis rosea (PR).
To compare histopathology between herald patches and secondary lesions.
To analyze differences between recent and older PR lesions.

Main Methods:

Histopathologic examination of 50 skin biopsies from pityriasis rosea patients.
Inclusion of 9 biopsies from herald patches.
Comparison of recent versus older lesions and herald patches versus secondary lesions.

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Main Results:

Key findings included decreased granular cell layer, red blood cell extravasation, dyskeratosis, basal cell liquefaction, and papillary collagen homogenization.
Prominent epidermal 'delling' and spongiotic patterns were observed.
Herald patches showed minor histopathologic differences compared to secondary lesions.

Conclusions:

Pityriasis rosea exhibits distinct histopathologic features differentiating it from dermatitis.
Epidermal 'delling' and spongiotic patterns are notable findings in PR.
Histologic similarities exist between herald patches and secondary lesions, with subtle variations.