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Related Experiment Video

Updated: Jun 8, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Squamous cell carcinoma arising from Gumma.

K Pavithran¹, N Riyaz

¹Department of Dermato-Venereology, Medical College Hospital, Calicut - 673 008, India.

Indian Journal of Dermatology, Venereology and Leprology

|September 30, 2010

Summary

Syphilitic gumma, a rare manifestation of syphilis, can exceptionally develop into squamous cell carcinoma. This case highlights the rare occurrence of this dual pathology, emphasizing the need for vigilance.

Area of Science:

Medicine
Pathology
Oncology

Background:

Syphilitic gumma, a tertiary syphilis manifestation, is infrequently encountered in modern clinical practice.
Malignant transformation of syphilitic gumma into squamous cell carcinoma is an exceedingly rare event.

Purpose of the Study:

To report a rare case of squamous cell carcinoma arising from a syphilitic gumma.
To contribute to the limited literature on this dual pathology.

Main Methods:

Case report detailing clinical presentation, diagnostic workup, and histopathological findings.
Review of relevant medical literature.

Main Results:

A confirmed diagnosis of squamous cell carcinoma originating within a syphilitic gumma was established.

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Last Updated: Jun 8, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

The case underscores the potential for neoplastic development in chronic syphilitic lesions.

Conclusions:

This case highlights an extremely rare but significant clinical observation.
Clinicians should maintain awareness of potential malignant transformation in persistent syphilitic gummas.