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Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
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Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

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Related Experiment Video

Updated: Jun 8, 2026

Rectal Organoid Morphology Analysis (ROMA): A Diagnostic Assay in Cystic Fibrosis
07:56

Rectal Organoid Morphology Analysis (ROMA): A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Rowell's Syndrome.

A Dogra1, Y C Minocha, M Gupta

  • 1Department of Dermatology, Venereology, Dayanand Medical College and Hospital, Ludhiana- 141 001, India.

Indian Journal of Dermatology, Venereology and Leprology
|September 30, 2010
PubMed
Summary
This summary is machine-generated.

This study details a lupus erythematosus case presenting with erythema multiforme-like lesions. Investigations confirmed the diagnosis with positive immunological markers and consistent histology.

Related Experiment Videos

Last Updated: Jun 8, 2026

Rectal Organoid Morphology Analysis (ROMA): A Diagnostic Assay in Cystic Fibrosis
07:56

Rectal Organoid Morphology Analysis (ROMA): A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Lupus erythematosus is a chronic autoimmune disease.
  • Erythema multiforme is an acute, immune-mediated condition.
  • Co-occurrence of these conditions presents diagnostic challenges.

Purpose of the Study:

  • To describe a case of lupus erythematosus with atypical skin manifestations.
  • To highlight the diagnostic process for complex dermatological presentations.

Main Methods:

  • Clinical case presentation.
  • Review of patient history and symptoms.
  • Immunological investigations including rheumatoid factor and antinuclear factor (ANF) testing.
  • Histopathological examination of skin lesions.

Main Results:

  • The patient, a 65-year-old woman, had a history of lupus erythematosus.
  • She presented with recurrent erythema multiforme-like skin lesions.
  • Immunological tests were positive for rheumatoid factor and ANF.
  • Histology confirmed the clinical findings consistent with lupus erythematosus.

Conclusions:

  • Lupus erythematosus can manifest with diverse and unusual skin lesions.
  • Comprehensive immunological and histological evaluation is crucial for accurate diagnosis.
  • Understanding atypical presentations aids in managing complex autoimmune diseases.