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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

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Assessing glycemic variation: why, when and how?

Fergus J Cameron¹, Peter A Baghurst, David Rodbard

¹Department of Endocrinology and Diabetes, Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute Parkville, Melbourne, Victoria 3052, Australia. fergus.cameron@rch.org.au

Pediatric Endocrinology Reviews : PER

|September 30, 2010

Summary

This summary is machine-generated.

Glycosylated hemoglobin (A1C) is insufficient for managing type 1 diabetes mellitus (T1DM). Glycemic variation (GV), measured by continuous glucose monitoring (CGM), offers new insights into metabolic control and diabetes complications.

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Area of Science:

Endocrinology
Metabolic Research
Diabetes Technology

Background:

Glycosylated hemoglobin (A1C) has been the primary clinical outcome in type 1 diabetes mellitus (T1DM) care.
A1C explains only about 25% of the risk for microvascular complications.
Emerging research highlights the significance of glucose's transcription-regulating actions and metabolic memory.

Purpose of the Study:

To review the importance of measuring glycemic variation (GV) in T1DM management.
To discuss the optimal circumstances for assessing GV.
To explore the most suitable GV metrics for different clinical purposes.

Main Methods:

Review of current literature on glycemic variation (GV) and its measurement.
Analysis of the role of continuous glucose monitoring (CGM) in assessing GV.
Discussion of the relationship between GV, metabolic control, and diabetes complications.

Main Results:

A1C alone is a limited predictor of T1DM complications.
Continuous glucose monitoring (CGM) enables the assessment of glycemic variation (GV).
GV is increasingly recognized for its association with oxidative stress and microvascular pathology.

Conclusions:

There is a need for consensus on the clinical significance and measurement of GV in T1DM.
GV assessment, facilitated by CGM, may provide a more comprehensive understanding of metabolic control.
Further research is needed to establish standardized GV metrics for clinical practice.