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Related Concept Videos

The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
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The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information about...
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Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Updated: Jun 8, 2026

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
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Published on: February 3, 2018

Nanotoxicology: no small matter.

Neus Feliu1, Bengt Fadeel

  • 1Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13. 171 77, Stockholm, Sweden.

Nanoscale
|September 30, 2010
PubMed
Summary
This summary is machine-generated.

Engineered nanomaterials offer technological advances but pose health and environmental risks. High-throughput screening methods are explored to assess these engineered nanomaterial hazards.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Toxicology

Background:

  • Engineered nanomaterials (ENMs) present novel applications in medicine and technology.
  • The widespread use of ENMs necessitates evaluation of their potential health and environmental impacts.
  • Existing toxicological approaches may require adaptation for nanoscale materials.

Purpose of the Study:

  • To review the applicability of high-throughput screening (HTS) methods for assessing ENM hazards.
  • To discuss the evolving role of toxicology in the context of nanoscale research.
  • To highlight the need for efficient safety assessment strategies for ENMs.

Main Methods:

  • Literature review of HTS applications in nanotoxicology.
  • Analysis of current toxicological paradigms for nanomaterials.
  • Discussion of disciplinary shifts in toxicology.

Main Results:

  • HTS offers a promising avenue for efficient hazard assessment of ENMs.
  • Adaptation of toxicological principles is crucial for evaluating nanoscale materials.
  • The field of nanotoxicology requires interdisciplinary collaboration.

Conclusions:

  • High-throughput screening is a valuable tool for evaluating the safety of engineered nanomaterials.
  • Toxicology must evolve to address the unique challenges posed by nanomaterials.
  • Further research is needed to develop standardized HTS protocols for ENMs.