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Updated: Jun 8, 2026
08:51
Quantification of Coenzyme A in Cells and Tissues
Published on: September 27, 2019
Cobalamin- and corrinoid-dependent enzymes
1Department of Biological Chemistry and Life Sciences Institute, University of Michigan, Ann Arbor MI 48109-2216, USA rmatthew@umich.edu.
Metal Ions in Life Sciences
|September 30, 2010
Summary
This review covers cobalamin and corrinoid enzymes, essential for methyl transfer and radical generation. These enzymes utilize methylcobalamin or adenosylcobalamin prosthetic groups for critical biochemical reactions.
Area of Science:
- Biochemistry
- Enzymology
- Molecular Biology
Background:
- Cobalamin and corrinoids are vital cofactors in numerous biological processes.
- Enzymes utilizing these cofactors play crucial roles in metabolism and cellular function.
Purpose of the Study:
- To review the literature on cobalamin- and corrinoid-containing enzymes.
- To categorize these enzymes based on their prosthetic groups and catalytic mechanisms.
Main Methods:
- Literature review of scientific publications.
- Classification of enzymes based on prosthetic groups (methylcobalamin, adenosylcobalamin).
- Analysis of catalyzed reactions (methyl transfer, radical generation).
Main Results:
- Identified two main classes of cobalamin/corrinoid enzymes.
- Class 1: Methylcobalamin-dependent enzymes catalyzing methyl transfer.
- Class 2: Adenosylcobalamin-dependent enzymes catalyzing radical generation for rearrangements/eliminations.
Conclusions:
- Cobalamin and corrinoid enzymes are diverse and essential for key metabolic pathways.
- Understanding their mechanisms provides insights into fundamental biochemical processes.
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