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Heptanol effects on protected livers.

G Kehrer1, A Aminalai, E Bürger

  • 1Abteilung Vegetative Physiologie und Pathophysiologie, Universität Göttingen.

Zeitschrift Fur Gastroenterologie
|December 1, 1990
PubMed
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Heptanol, an agent that closes gap junctions, alters liver electrical impedance during ischemia. This uncoupling effect is detectable via impedance measurements and influences energy turnover.

Area of Science:

  • Biophysics
  • Physiology
  • Biochemistry

Background:

  • Gap junctions regulate intercellular communication in various organs.
  • Heptanol is known to induce gap junction closure.
  • Electrical impedance can reflect cellular and tissue changes.

Purpose of the Study:

  • To investigate the effect of heptanol-induced gap junction uncoupling on liver electrical impedance during ischemia.
  • To determine if electrical impedance measurements can detect heptanol-induced uncoupling.

Main Methods:

  • Swine livers were perfused with solutions containing heptanol or a control solution.
  • Electrical impedance (phase angle at 5 kHz), pH, and biochemical parameters were measured during subsequent ischemia.
  • Heptanol was added to modified HTK and Belzer's UW-CSS solutions.

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Main Results:

  • Heptanol fundamentally altered the time course of electrical impedance.
  • The characteristic increase in the phase angle of impedance during ischemia was abolished by heptanol.
  • Heptanol caused a dose-dependent increase in the phase angle early in ischemia.
  • Heptanol stimulated anaerobic energy turnover.

Conclusions:

  • Heptanol-induced gap junction uncoupling significantly impacts liver electrical impedance.
  • Electrical impedance measurement is a viable method for detecting heptanol-induced uncoupling.
  • Heptanol exhibits both specific uncoupling effects and nonspecific influences on liver physiology during ischemia.