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The SAPHO syndrome: a clinical and imaging study
Meritxell Sallés1, Alejandro Olivé, Ricard Perez-Andres
1Rheumatology Section, Althaia, Avg. Bases de Manresa 6-8, Manresa, 08242, Spain. 35814msl@comb.cat
Clinical Rheumatology
|September 30, 2010
Summary
The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presents with distinct osteoarticular and cutaneous manifestations. This study highlights its homogenous clinical and radiological patterns, supporting its classification as an isolated entity.
Area of Science:
- Rheumatology
- Dermatology
- Radiology
Background:
- Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a complex condition with overlapping features.
- Understanding its distinct clinical and radiological profile is crucial for accurate diagnosis and management.
Purpose of the Study:
- To delineate the clinical and radiological manifestations of patients diagnosed with SAPHO syndrome.
- To evaluate the temporal relationship between osteoarticular and cutaneous involvement.
Main Methods:
- Retrospective analysis of 52 patients diagnosed with SAPHO syndrome between 1984 and 2007.
- Data collection included clinical presentation, cutaneous and osteoarticular findings, HLA B27 status, bone scintigraphy, and CT scans.
Main Results:
- Anterior chest pain (73%) and peripheral arthritis (32%) were the most common clinical features; 63.5% had cutaneous involvement.
- Osteoarticular involvement preceded or coincided with cutaneous manifestations in the majority of patients.
- Bone scintigraphy revealed increased uptake in 93.3% of patients, predominantly in sternoclavicular and manubriosternal joints; CT confirmed sclerosis, erosions, and hyperostosis.
Conclusions:
- SAPHO syndrome exhibits a characteristic and homogenous clinical and radiological pattern.
- These findings support the classification of SAPHO syndrome as a distinct clinical entity.
- Pamidronate was a primary treatment for refractory cases.
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