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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
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Published on: July 7, 2023

Distant metastases do not metastasize.

Dieter Hölzel1, Renate Eckel, Rebecca T Emeny

  • 1Munich Cancer Registry (MCR) of Munich Comprehensive Cancer Centre, Ludwigs-Maximilians-University, Marchionistr. 15, 81377 Munich, Germany. hoe@ibe.med.uni-muenchen.de

Cancer Metastasis Reviews
|September 30, 2010
PubMed
Summary
This summary is machine-generated.

Distant metastases (MET) are critical in most cancers. This study suggests MET are initiated before primary tumor removal and grow slowly, impacting cancer treatment strategies.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Metastasis

Background:

  • Distant metastases (MET) are a primary cause of mortality in most solid cancers.
  • Survival post-metastasis varies significantly by cancer type and prognostic factors.
  • The metastatic process within biological subgroups is remarkably homogenous.

Purpose of the Study:

  • To estimate the initiation time of distant metastases (MET) based on their growth rate.
  • To hypothesize that most MET are initiated before primary tumor removal.
  • To explore the implications of MET initiation timing on cancer diagnosis and treatment.

Main Methods:

  • Estimating MET growth rate from initiation to diagnosis and death.
  • Utilizing breast cancer volume doubling time to estimate the earliest possible dissemination.
  • Generalizing findings across solid cancers, though breast cancer data was primary.

Main Results:

  • The growth rate of MET can be estimated, allowing for initiation time calculation.
  • Hypothesized that nearly all MET originate before primary tumor resection.
  • Proposed that MET do not reach clinically significant size before diagnosis.

Conclusions:

  • MET initiation timing has significant implications for diagnostic and therapeutic strategies.
  • The hypotheses suggest a re-evaluation of treatment timing and clinical trial design.
  • Understanding MET initiation is crucial for improving patient outcomes in solid cancers.