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Updated: Jun 8, 2026

Teratoma Generation in the Testis Capsule
Published on: November 7, 2011
What's growing on? The growing teratoma syndrome
Luca Denaro1, Francesca Pluchinotta, Roberto Faggin
1Academic Neurosurgery, Department of Neurosciences, University of Padova, Via Giustiniani N 5, 35128, Padua, Italy.
Background:
The growing teratoma syndrome (GTS) consists of a mature teratoma paradoxically enlarging during or after chemotherapy for malignant nongerminomatous germ cell tumors.
Methods And Results:
We report two cases of GTS occurring in association with NSGCT of the pineal gland. Although an unusual event, clinicians and radiologists should be aware of its natural history.
Conclusions:
When normalized tumor markers after chemotherapy are associated with imaging features of a growing mass, the hypothesis of GTS must be taken in consideration. When early diagnosed, GTS can be managed surgically with good results.
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