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Updated: May 4, 2026

Hydrolysis of a Ni-Schiff-Base Complex Using Conditions Suitable for Retention of Acid-labile Protecting Groups
Published on: April 6, 2017
Highly practical amino acid and alkaloid synthesis using designer chiral phase transfer catalysts as high-performance
1Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. maruoka@kuchem.kyoto-u.ac.jp
Abstract:
A series of chiral quaternary ammonium salts derived from commercially available (R)- or (S)-binaphthol have been designed as new C(2)-symmetric chiral phase transfer catalysts. In order to realize the flexible design of these phase transfer catalysts, the combinatorial design approach has been developed. These chiral high-performance organocatalysts have been successfully applied to the highly practical asymmetric synthesis of various amino acid derivatives including α-alkyl and α,α-dialkyl-α-amino acids in addition to alkaloids.
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