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Pulmonary Structural MRI using Free-Breathing, Self-Gated Ultra-short Echo Time Imaging
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A modified EPI sequence for high-resolution imaging at ultra-short echo time.

Stefan Hetzer1, Toralf Mildner, Harald E Möller

  • 1Nuclear Magnetic Resonance Unit, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Magnetic Resonance in Medicine
|September 30, 2010
PubMed
Summary

Double-shot echo-planar imaging with center-out trajectories and intrinsic navigation (DEPICTING) enables ultra-short echo time imaging. This robust modification achieves high temporal efficiency and corrects imperfections for advanced brain imaging applications.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Physics
  • Neuroimaging

Background:

  • Conventional echo-planar imaging (EPI) faces limitations in achieving ultra-short echo times.
  • Balancing temporal efficiency and image quality remains a challenge in rapid MRI acquisition.

Purpose of the Study:

  • To introduce and validate a novel EPI technique, DEPICTING, for ultra-short echo time imaging.
  • To improve spatial and temporal resolution in MRI for enhanced neuroimaging capabilities.

Main Methods:

  • Developed double-shot EPI with center-out trajectories and intrinsic navigation (DEPICTING).
  • Implemented k-space data acquisition using two center-out trajectories with minimal delay.
  • Utilized intrinsic navigator information for intersegment phase and intensity correction.
  • Applied k-space-based correction for main magnetic field inhomogeneities.

Main Results:

  • Achieved ultra-short echo times (<2 msec), nearly independent of acquisition matrix size.
  • Demonstrated temporal efficiency comparable to conventional single-shot EPI.
  • Successfully corrected phase and intensity imperfections.
  • Recovered superior point-spread function characteristic of center-out trajectories.

Conclusions:

  • DEPICTING offers a robust method for ultra-short echo time MRI.
  • The technique enables simultaneous high spatial and temporal resolution imaging.
  • Validated applications include anatomical imaging, BOLD functional brain mapping, and quantitative perfusion imaging.