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Related Concept Videos

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

Updated: Jun 8, 2026

Micro-CT Imaging and Morphometric Analysis of Mouse Neonatal Brains
06:36

Micro-CT Imaging and Morphometric Analysis of Mouse Neonatal Brains

Published on: May 19, 2023

Combining morphological information in a manifold learning framework: application to neonatal MRI.

P Aljabar1, R Wolz, L Srinivasan

  • 1Department of Computing, Imperial College London, UK. Paul.Aljabar@Imperial.ac.uk

Medical Image Computing and Computer-Assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
|October 1, 2010
PubMed
Summary

This study introduces a new framework using multiple MR image measures for a comprehensive neonatal brain morphology representation. Combining shape and appearance data improves characterization of brain development trajectories.

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Last Updated: Jun 8, 2026

Micro-CT Imaging and Morphometric Analysis of Mouse Neonatal Brains
06:36

Micro-CT Imaging and Morphometric Analysis of Mouse Neonatal Brains

Published on: May 19, 2023

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
08:49

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Published on: August 1, 2022

Area of Science:

  • Neuroimaging
  • Medical Image Analysis
  • Developmental Neuroscience

Background:

  • Single MR image measures are insufficient for comprehensive morphological characterization.
  • Neonatal brain development involves rapid changes in shape and image appearance.

Purpose of the Study:

  • To develop a framework combining multiple MR image measures for improved population representation.
  • To characterize neonatal brain development trajectories using a unified morphological representation.

Main Methods:

  • Utilizing manifold learning to generate coordinate embeddings from multiple MR image measures.
  • Combining shape (deformation metric) and appearance (image similarity) measures.
  • Applying the framework to neonatal brain MRI data.

Main Results:

  • The combined embeddings provide biologically plausible and consistent representations of neonatal brain morphology.
  • Orthogonal correlations suggest independent morphological feature representation.
  • Improved correlations with clinical data demonstrate the benefit of combining embeddings.

Conclusions:

  • The proposed framework offers a superior method for characterizing neonatal brain development.
  • Integrating diverse MR image measures enhances the understanding of complex morphological changes.
  • This approach has potential for improved clinical data correlation and developmental analysis.