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Updated: Jun 8, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
Inner ear drug delivery system from the clinical point of view
Tatsunori Sakamoto1, Takayuki Nakagawa, Rie T Horie
1Department of Otolaryngology, Head and Neck Surgery, Kyoto University, Kyoto, Japan. sakamoto@ent.kuhp.kyoto-u.ac.jp
Conclusion:
Three types of inner ear drug delivery systems (DDS) that were ready to be applied in clinics were developed.
Objectives:
To develop clinically applicable inner ear DDS for the treatment of inner ear disorders.
Methods:
Inner ear DDS using clinically applicable materials were developed and evaluated.
Results:
The systemic application of stealth-type nanoparticles encapsulating betamethasone provided superior therapeutic results for the treatment of noise-induced hearing loss compared with the systemic application of betamethasone in mice. Microparticles made of biodegradable polymer (poly (lactic/glycolic) acid, PLGA) encapsulating lidocaine were placed on the round window membrane of guinea pigs, and resulted in reasonable concentrations of lidocaine in the cochlea without serious adverse effects. The phase I/IIa clinical trial of the application of insulin-like growth factor-1 (IGF-1) in combination with gelatin hydrogel on the round window membrane was conducted, recruiting patients with acute sensorineural hearing loss after the failure of systemic application of steroids.
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