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Updated: Oct 13, 2026

08:47
Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
Published on: November 8, 2018
Modulation of neuronal activity of locus coeruleus in rats induced by excitatory amino acids
1Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing.
Abstract:
The excitatory actions on the unit activities of locus coeruleus induced by excitatory amino acids were studied. Quinolinic acid 10 nmol and N-methyl-D-aspartate (NMDA) 4 nmol icv markedly increased unit discharge of locus coeruleus neurons. The excitatory action was fully antagonized by icv 4 nmol D,L-2-amino-7-phosphonoheptanoic acid, a specific NMDA receptor antagonist. Excitatory effect induced by quinolinic acid is possibly mediated by excitatory amino acid receptors in locus coeruleus.

