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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
What is the Immune System?01:38

What is the Immune System?

Overview

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Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
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Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

Silicone and autoimmunity.

Steven D Hajdu1, Nancy Agmon-Levin, Yehuda Shoenfeld

  • 1The Zabludowicz Center for Autoimmune Diseases and Department of Medicine B, The Chaim Sheba Medical Center, Tel Hashomer, Israel.

European Journal of Clinical Investigation
|October 1, 2010
PubMed
Summary
This summary is machine-generated.

Silicone breast implants can cause inflammation and autoimmune issues like siliconosis in a small number of patients. Further research is needed to identify risk factors for these adverse effects.

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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
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11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Area of Science:

  • Biomaterials Science
  • Immunology
  • Plastic Surgery

Background:

  • Silicone implants have been used for breast augmentation since the 1960s.
  • A US FDA moratorium (1992-2006) raised safety concerns.
  • Despite the moratorium's removal, adverse effects remain a concern.

Purpose of the Study:

  • To review the safety and adverse effects of silicone breast implants.
  • To investigate the link between silicone implants and autoimmune phenomena.
  • To identify potential risk factors for adverse outcomes.

Main Methods:

  • Literature review of studies on silicone breast implants.
  • Analysis of reported local and systemic adverse effects.
  • Examination of evidence for carcinogenesis and autoimmunity.

Main Results:

  • Inflammatory fibro-proliferative response and capsular contracture are established risks.
  • No link to carcinogenesis was found.
  • A plausible link to autoimmune phenomena ('siliconosis') exists in a minority of patients.

Conclusions:

  • Further research is needed to elucidate environmental and genetic risk factors for siliconosis.
  • Identifying autoimmune risk factors could help predict long-term patient health.
  • Interventions like texturized implants and Zafirlukast may mitigate fibro-proliferative responses.