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In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
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Microglial activation and chronic neurodegeneration

Melinda E Lull1, Michelle L Block

  • 1Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, Virginia 23298, USA.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|October 1, 2010
PubMed
Summary

Activated microglia release neurotoxic factors, driving neuron damage in neurodegenerative diseases. Reactive microgliosis and reactive oxygen species (ROS) are key to this chronic, toxic microglial phenotype, especially in Parkinson's disease.

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