Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 8, 2026

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
15:08

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

Targeting astrocytes for stroke therapy.

Yanxin Zhao1, David A Rempe

  • 1Department of Neurology in the Center for Neural Development and Disease, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|October 1, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel nomogram based on preoperative inflammatory indicators and postoperative clinicopathological features for predicting metachronous liver metastasis of colorectal cancer.

BMC surgery·2026
Same author

Brain endothelial cell-derived extracellular vesicles (c-BEEVs) as a promising biomarker for brain vascular pathology and cognitive decline.

Nature aging·2026
Same author

Janus Reaction-Zone Catalytic Membrane for Sequential and Selective Degradation of Multiple Micropollutants: Performance and Mechanistic Insights.

Environmental science & technology·2026
Same author

Intra-arterial Alteplase Thrombolysis After Successful Thrombectomy for AIS in the Posterior Circulation: The IAT-TOP Randomized Clinical Trial.

JAMA neurology·2026
Same author

Plasma-derived small extracellular vesicle miR-660-5p as a predictor for carotid plaque vulnerability and postoperative major adverse cardiovascular event risk.

Atherosclerosis plus·2026
Same author

Association between the atherogenic index of plasma and metabolic-associated/nonalcoholic fatty liver disease: a systematic review and meta-analysis.

Frontiers in endocrinology·2026

Astrocyte (star-shaped glial cells) roles in stroke are complex, impacting both neuronal survival and recovery. Targeting astrocyte functions, both beneficial and detrimental, offers new therapeutic avenues for stroke patients.

Area of Science:

  • Neuroscience
  • Neurology
  • Cell Biology

Background:

  • Stroke is a leading cause of death and disability, with current treatments showing limited efficacy.
  • Previous neurotherapeutic trials targeting neuronal cell death mechanisms have failed to improve outcomes.
  • Astrocytes, crucial for neuronal survival and function, play a dual role in stroke pathology.

Purpose of the Study:

  • To review the multifaceted roles of astrocytes in stroke.
  • To explore both the neuroprotective and detrimental effects of astrocytes during and after stroke.
  • To identify potential therapeutic targets within astrocyte biology for stroke recovery.

Main Methods:

  • Literature review of preclinical and clinical studies on astrocyte function in stroke.

More Related Videos

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

Related Experiment Videos

Last Updated: Jun 8, 2026

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
15:08

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

  • Analysis of astrocyte-mediated mechanisms influencing neuronal viability, inflammation, and repair.
  • Examination of past and potential future clinical trials targeting astrocytes.

    • Main Results:

    • Astrocytes support neuronal viability through glutamate uptake and neurotrophin release.
    • Under certain conditions, astrocytes can exacerbate damage via inflammatory mediators or glutamate release.
    • Astrocytes contribute to post-stroke angiogenesis, neuronal plasticity, and functional recovery.

    Conclusions:

    • Astrocytes exert both positive and negative influences on brain tissue during stroke.
    • Targeting astrocyte functions presents a promising strategy for novel stroke therapies.
    • Further research into modulating astrocyte behavior could significantly improve stroke patient recovery.