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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
[Renal sarcoidosis: a series of five patients]
M Le Besnerais1, A François, F Leroy
1Département de médecine interne, CHU de Rouen-Boisguillaume, 1 rue de Germont, Rouen cedex, France.
Introduction:
Renal involvement is uncommon in sarcoidosis, occurring in less than 5% of the patients. Diagnostic delay should be minimal to improve the outcome.
Methods:
From 1996 to 2009, 78 patients were seen for sarcoidosis in the Department of Internal Medicine of Rouen University hospital.
Results:
Five patients (6.4%) had renal involvement. Diagnosis of renal involvement and sarcoidosis were concomitant in two patients while in the three remaining patients, renal manifestations occurred during the course of sarcoidosis. The five patients with renal manifestations exhibited: isolated sarcoid granulomatous interstitial nephritis (n=2), sarcoid granulomatous interstitial nephritis and nephrocalcinosis (n=2), renal failure due to hypercalcemia (n=1).
Conclusion:
This series underlines that renal function tests should be performed systematically both during initial evaluation and the follow-up of patients with sarcoidosis.
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