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Updated: Jun 8, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

[Prevention of early-onset group B Streptococcus infections. 2. Efficiency of the ANAES guidelines]

C Muris1, M Lemonnier, M Herlicoviez

  • 1Service de gynécologie-obstétrique et médecine de la reproduction, CHU, boulevard Georges-Clémenceau, 14033 Caen cedex, France. murisguillou@free.fr

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|October 1, 2010
PubMed

Insights

The ANAES guidelines effectively reduced early-onset neonatal infections by screening for Group B Streptococcus. However, this led to increased antibiotic use, impacting bacterial ecology.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Public Health

Context:

  • Early-onset neonatal infections pose significant risks.
  • Current prophylaxis strategies require evaluation for efficacy and impact.
  • Group B Streptococcus (GBS) is a primary concern in neonatal infections.

Purpose:

  • To evaluate the effectiveness of ANAES guidelines for early-onset infection prophylaxis.
  • To assess the impact of systematic prenatal GBS screening and risk factor analysis during delivery.
  • To compare infection rates before and after guideline implementation.

Summary:

  • A retrospective cohort study analyzed 12,266 deliveries over 56 months.
  • The ANAES protocol, involving prenatal GBS screening, decreased overall early-onset infections (1.50% vs 2.02%).
  • A risk-factor-only strategy would have missed 23 GBS-infected newborns, highlighting the value of screening.

Impact:

  • The protocol successfully prevented early-onset infections, demonstrating its clinical utility.
  • A significant increase in antibiotic consumption was observed, raising concerns about bacterial resistance and ecology.
  • Further research is needed to balance infection prevention with judicious antibiotic stewardship.
Abstract

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