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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood
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[Biological therapy in pediatrics].

A Belot1, P Cochat

  • 1Service de néphrologie et rhumatologie pédiatrique, hôpital Femme-Mère-Enfant, hospices civils de Lyon, université de Lyon, 69677 Bron cedex, France. alexbelot@yahoo.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|October 1, 2010
PubMed
Summary
This summary is machine-generated.

Biological therapies, including monoclonal antibodies, offer targeted immune modulation for pediatric patients. Further clinical trials are essential to confirm the long-term safety and efficacy of these vital treatments in children.

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Area of Science:

  • Immunology and Pharmacology
  • Pediatric Therapeutics

Context:

  • The evolution of biological therapies in pediatric medicine began with murine monoclonal antibodies like muromonab in the late 1980s for organ transplantation.
  • Numerous novel biological agents have since been developed, targeting immune responses, growth factors, and infections through antigen-specific mechanisms.

Purpose:

  • To review the current landscape of biological therapies in pediatric care, highlighting their off-label use, effectiveness, and potential as first-line treatments.
  • To emphasize the specific targeting capabilities of biologicals and the critical need for understanding their safety profiles in children.

Summary:

  • Biological therapies, while often used off-label in pediatrics, demonstrate significant effectiveness and tolerability, even serving as primary treatments for certain genetic disorders.
  • These agents offer precise antigen targeting but require careful monitoring due to variable safety profiles.
  • The development pipeline for pediatric biologicals necessitates robust clinical trials to establish medium- and long-term safety and efficacy.

Impact:

  • Advances in biologicals offer tailored treatment strategies for pediatric diseases, improving patient outcomes.
  • The findings underscore the importance of ongoing research and clinical validation to ensure the safe and effective integration of these powerful therapies into pediatric practice.