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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Updated: Mar 4, 2026

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions

Published on: October 20, 2020

Driving biochemical discovery with quantitative proteomics.

Michael P Washburn¹

¹Stowers Institute for Medical Research, Kansas City, 1000 E. 50(th) St., MO 64110, USA. mpw@stowers.org

Trends in Biochemical Sciences

|October 1, 2010

Summary

This summary is machine-generated.

Quantitative proteomics, a powerful discovery tool, advances biological research by revealing novel insights into protein complexes and modifications. New mass spectrometry methods enhance its application in modern scientific studies.

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Area of Science:

Biochemistry
Molecular Biology
Proteomics

Background:

Proteomic analysis is crucial for modern biological research.
Proteomics serves as a discovery tool, generating new research hypotheses.
Advancements in proteomics technologies are rapidly emerging.

Purpose of the Study:

To highlight the growing importance of quantitative proteomics.
To emphasize the application of new proteomics methods.
To showcase the utility of proteomics in generating novel insights.

Main Methods:

Mass spectrometry-based quantitative proteomics.
Development and application of new proteomics technologies.
Analysis of biological samples.

Main Results:

Quantitative proteomics provides significant insights into protein complexes.
Quantitative proteomics enhances understanding of post-translational modifications.
New methods have been successfully applied across various biochemical studies.

Conclusions:

Quantitative proteomics is a key discovery tool in contemporary research.
Advancements in mass spectrometry-based methods drive new insights.
Proteomics facilitates a deeper understanding of complex biological systems.