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Imaging in clinical trials

P Murphy1, D-M Koh

  • 1Oncology R&D, GlaxoSmithKline, Uxbridge, UK.

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
|October 1, 2010
PubMed

Insights

Drug development faces challenges, necessitating early efficacy and safety assessments. Advanced imaging techniques are crucial for evaluating novel therapeutics in clinical trials, but standardization remains a key issue.

Area of Science:

  • Oncology
  • Drug Development
  • Medical Imaging

Background:

  • Drug development is costly and faces challenges in progressing candidates through clinical trials.
  • There is a need for methods to characterize early drug efficacy and safety.
  • Imaging techniques are increasingly utilized in oncological clinical trials for decision-making.

Purpose of the Study:

  • To highlight the role of imaging in oncological clinical trials.
  • To discuss the application of conventional and functional imaging in evaluating novel therapeutics.
  • To address the challenges of standardizing multi-center imaging in clinical trials.

Main Methods:

  • Review of conventional morphological imaging techniques and standardized response criteria.
  • Exploration of the potential role of functional imaging techniques.
  • Identification of challenges in multi-center imaging standardization, including acquisition, analysis, and review.

Main Results:

  • Conventional imaging, based on tumor size, is used for study endpoints.
  • Functional imaging holds promise for novel therapeutic evaluation but requires established application methods.
  • Standardization of multi-center imaging presents significant challenges.

Conclusions:

  • Imaging is vital in oncological clinical trials for assessing drug efficacy and safety.
  • Functional imaging offers potential for evaluating new therapeutics, but optimal application needs definition.
  • Addressing standardization issues in multi-center imaging is critical for reliable clinical trial outcomes.

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