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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
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Imaging in clinical trials.

P Murphy1, D-M Koh

  • 1Oncology R&D, GlaxoSmithKline, Uxbridge, UK.

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
|October 1, 2010
PubMed
Summary
This summary is machine-generated.

Drug development faces challenges, necessitating early efficacy and safety assessments. Advanced imaging techniques are crucial for evaluating novel therapeutics in clinical trials, but standardization remains a key issue.

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Area of Science:

  • Oncology
  • Drug Development
  • Medical Imaging

Background:

  • Drug development is costly and faces challenges in progressing candidates through clinical trials.
  • There is a need for methods to characterize early drug efficacy and safety.
  • Imaging techniques are increasingly utilized in oncological clinical trials for decision-making.

Purpose of the Study:

  • To highlight the role of imaging in oncological clinical trials.
  • To discuss the application of conventional and functional imaging in evaluating novel therapeutics.
  • To address the challenges of standardizing multi-center imaging in clinical trials.

Main Methods:

  • Review of conventional morphological imaging techniques and standardized response criteria.
  • Exploration of the potential role of functional imaging techniques.
  • Identification of challenges in multi-center imaging standardization, including acquisition, analysis, and review.

Main Results:

  • Conventional imaging, based on tumor size, is used for study endpoints.
  • Functional imaging holds promise for novel therapeutic evaluation but requires established application methods.
  • Standardization of multi-center imaging presents significant challenges.

Conclusions:

  • Imaging is vital in oncological clinical trials for assessing drug efficacy and safety.
  • Functional imaging offers potential for evaluating new therapeutics, but optimal application needs definition.
  • Addressing standardization issues in multi-center imaging is critical for reliable clinical trial outcomes.