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Parathyroid hormone stimulates circulating osteogenic cells in hypoparathyroidism
M R Rubin1, J S Manavalan, D W Dempster
1Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. mrr6@columbia.edu
The Journal of Clinical Endocrinology and Metabolism
|October 1, 2010
Summary
Parathyroid hormone (PTH) treatment increases circulating osteogenic cells in hypoparathyroid patients, promoting bone formation. This study confirms PTH stimulates osteoblast development and maturation, enhancing bone health.
Area of Science:
- Endocrinology
- Bone Biology
- Cell Biology
Background:
- Parathyroid hormone (PTH) is known for its osteoanabolic effects, potentially mediated by increasing the number and maturity of circulating osteogenic cells.
- Hypoparathyroidism serves as a valuable clinical model to investigate the role of PTH in regulating osteogenic cells.
Purpose of the Study:
- To characterize circulating osteogenic cells in hypoparathyroid subjects receiving PTH (1-84) over 12 months.
- To evaluate the impact of PTH administration on osteoblast development and maturation.
Main Methods:
- Flow cytometry was used to analyze osteogenic cells, employing antibodies for osteocalcin and stem cell markers (CD34, CD146).
- Biochemical markers of bone formation and bone biopsies were correlated with circulating osteogenic cell measurements.
- The study included 19 hypoparathyroid patients and 19 controls, with PTH (1-84) as the intervention.
Main Results:
- Hypoparathyroid subjects had lower osteocalcin-positive cells compared to controls, with higher coexpression of CD34 and CD146.
- PTH (1-84) administration led to a threefold increase in osteogenic cells and a decrease in CD34/CD146 coexpression.
- Increases in osteogenic cells strongly correlated with biochemical and histomorphometric indices of bone formation.
Conclusions:
- PTH likely stimulates bone formation by promoting osteoblast development and maturation.
- The methodology used effectively identifies osteoblast activity through circulating osteogenic cells and their correlation with bone formation markers.
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