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Published on: May 11, 2011
Permeability alterations after surgical trauma in normal rabbit peritoneum
V K Kouritas1, K Tepetes, G Christodoulides
1Department of Surgery, Larissa University Hospital, Larissa, Greece. kouritas @ otenet.gr
Summary
Surgical trauma impairs rabbit parietal peritoneum permeability. Icodextrin (ID) or normal saline (N/S) reversed this effect, while dimetindene maleate (DM) did not, indicating antiadhesion measures impact peritoneal physiology.
Area of Science:
- Peritoneal Physiology
- Surgical Trauma Research
- Drug Efficacy Studies
Background:
- Surgical trauma is known to affect peritoneal membrane function.
- Investigating the impact of anti-adhesion agents on peritoneal permeability is crucial for surgical outcomes.
Purpose of the Study:
- To determine how surgical trauma and specific agents (normal saline, icodextrin, dimetindene maleate) alter rabbit parietal peritoneum permeability.
- To assess the role of sodium channels in these permeability changes.
Main Methods:
- Utilized a rabbit model of adhesion formation with 45 female rabbits.
- Administered normal saline (N/S), icodextrin (ID), and/or dimetindene maleate (DM) post-surgery.
- Measured transmesothelial resistance (R(TM)) using Ussing chambers and amiloride to probe Na(+) channels.
Main Results:
- Surgical trauma increased R(TM), indicating reduced permeability, and partially blocked amiloride's effect.
- Icodextrin (ID) and normal saline (N/S) increased R(TM) and inhibited amiloride's action.
- Dimetindene maleate (DM) alone did not alter R(TM) or amiloride's effect; combined with ID, it increased R(TM) but blocked amiloride.
Conclusions:
- Surgical trauma significantly impairs parietal peritoneum permeability in rabbits.
- Icodextrin (ID) and normal saline (N/S) effectively counteract the permeability impairment caused by surgical trauma.
- Dimetindene maleate (DM) is ineffective as an antiadhesion measure in this model, highlighting differential effects of agents on peritoneal physiology.
