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Updated: Jun 8, 2026
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
CD4+ regulatory T cells in solid organ transplantation
1Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, Oxford, UK.
Current Opinion in Organ Transplantation
|October 1, 2010
Summary
Regulatory T cells (Tregs) show promise for improving long-term survival in solid organ transplantation. Emerging research and clinical trials suggest Treg therapy may soon be used in transplantation patients.
Area of Science:
- Immunology
- Transplantation Science
- Cellular Therapy
Background:
- Solid organ transplantation is a vital treatment for end-stage organ failure.
- Current long-term outcomes in transplantation remain suboptimal.
- CD4 regulatory T cells (Tregs) are being investigated for their potential to enhance allograft survival.
Purpose of the Study:
- To review the fundamental biology of CD4 Tregs.
- To examine recent experimental and clinical evidence supporting Treg therapy in solid organ transplantation.
Main Methods:
- Review of current literature on Treg biology and function.
- Analysis of experimental models investigating Treg behavior in transplantation.
- Evaluation of clinical trial data for Treg adoptive cellular therapy, particularly in graft-versus-host disease.
Main Results:
- Significant advancements have been made in Treg isolation and expansion techniques.
- Experimental models provide crucial insights into Treg activity in transplantation settings.
- Early clinical trials in graft-versus-host disease demonstrate the potential efficacy of Treg adoptive cellular therapy.
Conclusions:
- Accumulating evidence supports the therapeutic potential of Treg cellular therapy in transplantation.
- Clinical application of Treg therapy in solid organ transplantation is anticipated in the near future.
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