Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decoding pre-movement neural activity from thalamic LFPs for adaptive neurostimulation in tremor patients.

Neurocomputing·2026
Same author

Stimulation settings in subthalamic nucleus deep brain stimulation for parkinson's disease - a retrospective single-center observational study.

Neurological research and practice·2026
Same author

Corrigendum to tractography-guided versus clinical contact selection for deep brain stimulation in tremor - A prospective clinical trial.

Brain stimulation·2026
Same author

Multimodal Image Guidance in Subthalamic Deep Brain Stimulation for Parkinson's Disease.

Annals of neurology·2026
Same author

Comparison of neuropsychological side effects between contemporary radiofrequency ablative neurosurgery for psychiatric disorders and conventional neurosurgical procedures: systematic review and meta-analysis.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jun 8, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Experimental deep brain stimulation in animal models.

Sonny Kh Tan1, Rinske Vlamings, Leewei Lim

  • 1Department of Neuroscience, Maastricht University, Department of Neurosurgery, Maastricht University Medical Center, European Graduate School of Neuroscience (EURON), Maastricht Institute of Neuromodulative Development (MIND), Maastricht, The Netherlands.

Neurosurgery
|October 1, 2010
PubMed
Summary
This summary is machine-generated.

Experimental deep brain stimulation (DBS) in freely moving rats effectively models Parkinson's and Huntington's diseases. This research validates DBS technology and explores new therapeutic applications for neurological disorders.

More Related Videos

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
09:36

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Published on: March 23, 2022

Related Experiment Videos

Last Updated: Jun 8, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
09:36

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Published on: March 23, 2022

Area of Science:

  • Neurosurgery
  • Neuroscience
  • Animal Models

Background:

  • Deep Brain Stimulation (DBS) is a key therapy for neurological and psychiatric disorders.
  • Experimental DBS in animal models is crucial for evaluating new technologies and indications.

Purpose of the Study:

  • To review the development and validation of experimental DBS in freely moving rats.
  • To assess the efficacy of DBS in rat models of Parkinson's and Huntington's diseases.

Main Methods:

  • Developed a novel electrode construction for unilateral or bilateral DBS in rats.
  • Validated the technique in 6-hydroxydopamine-induced Parkinson's disease and transgenic Huntington's disease rat models.
  • Evaluated motor and cognitive functions using behavioral tasks.

Main Results:

  • Bilateral subthalamic nucleus DBS improved motor deficits in Parkinson's model but caused side effects.
  • Globus pallidus DBS ameliorated motor and cognitive symptoms in the Huntington's disease model.
  • Successful electrode placement in target areas ranged from 70% to 95%.

Conclusions:

  • Experimental DBS in freely moving rats is a viable tool for exploring new DBS indications and refining technology.
  • The developed electrode construction and methodology are effective for preclinical DBS research.
  • Findings highlight the potential and challenges of DBS therapy in neurological disease models.