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Related Experiment Video

Updated: Jun 8, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Preventing bone complications in advanced prostate cancer.

M A Luz¹, A G Aprikian

¹Division of Urology, Department of Surgery, McGill University, Montreal, QC.

Current Oncology (Toronto, Ont.)

|October 1, 2010

Summary

Prostate cancer bone complications, including those from androgen deprivation therapy (ADT), remain a challenge. This review focuses on preventing bone issues in advanced prostate cancer patients.

Keywords:

Prostate cancer bone metastases skeletal complications

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Last Updated: Jun 8, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Published on: March 6, 2018

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Area of Science:

Oncology
Bone Metabolism
Urology

Background:

Advanced prostate cancer frequently metastasizes to bone, impacting patient quality of life.
Androgen deprivation therapy (ADT), a standard treatment, paradoxically increases the risk of bone disease.
Effective management of bone complications is crucial for symptom control in prostate cancer patients.

Purpose of the Study:

To review strategies for preventing bone complications in prostate cancer.
To address bone metastases and ADT-induced bone loss.
To improve quality of life for patients with advanced prostate cancer.

Main Methods:

Literature review of studies on prostate cancer bone health.
Analysis of data on bone metastases and ADT-related bone complications.
Synthesis of current evidence on prevention and management.

Main Results:

Prostate cancer bone metastases present significant clinical challenges.
ADT contributes to decreased bone mineral density and increased fracture risk.
Multimodal approaches are necessary for comprehensive bone health management.

Conclusions:

Preventing bone complications is vital for advanced prostate cancer care.
Addressing both cancer-related and treatment-related bone issues is essential.
Further research is needed to optimize bone health strategies in prostate cancer patients.