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Treatment Resistent Cancers

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

Published on: October 2, 2014

Conquering cancer through discovery research.

William C S Cho¹

¹Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong. chocs@ha.org.hk

|October 1, 2010

Summary

Translational cancer medicine bridges basic research and patient care, advancing cancer detection and therapies. This review highlights key discoveries in cancer genomics, targeted agents, and clinical trials for better understanding and treatment.

Area of Science:

Translational Cancer Medicine
Molecular Oncology
Cancer Genomics

Background:

Cancer remains a major global health challenge, necessitating advancements in research and treatment.
Translational cancer medicine is crucial for converting scientific discoveries into clinical applications and vice versa.

Purpose of the Study:

To review recent advancements in translational cancer medicine.
To highlight the integration of basic research with clinical investigations in oncology.
To provide insights into the complexity of cancer through molecular, cellular, and clinical findings.

Main Methods:

Identification of 319 driver genes and 12 core cancer pathways.
Application of diagnostic tools like MammaPrint and OncoMap.

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Analysis of genome-wide association studies and microRNA networks.

Discussion of cancer stem cells, tumor microenvironment, and targeted therapies.

Review of clinical trial outcomes (e.g., STAR P-2, NeoBIG, BATTLE).

Main Results:

Significant progress in understanding cancer biology through genomic and molecular profiling.
Development of novel targeted agents including HDAC inhibitors, PARP inhibitors, and PI3K pathway inhibitors.
Demonstrated success of translational approaches in improving cancer detection and therapeutic strategies.

Conclusions:

The synergy between basic science and clinical research is vital for advancing cancer medicine.
Continued exploration of molecular and cellular mechanisms will drive the development of more effective cancer therapies.
Translational cancer medicine offers a promising pathway to better manage and treat cancer patients.