Related Experiment Video
Updated: Jun 8, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Mutations in the melanocortin-3 receptor (MC3R) gene: Impact on human obesity or adiposity
1Auburn University, Department of Anatomy, Physiology and Pharmacology, AL 36849-5519, USA. taoyaxi@auburn.edu
Abstract:
The melanocortin-3 receptor (MC3R), together with the related melanocortin-4 receptor (MC4R), are important regulators of energy homeostasis. Rodent studies have demonstrated that the two receptors have non-redundant roles in regulating energy balance. However, while mutations for the MC4R have been established as a cause of monogenic obesity, mutations in the MC3R gene remain controversially associated with human obesity pathogenesis. This editorial summarizes the current status of MC3R in rodent energy homeostasis and human obesity pathogenesis.
More Related Videos
Related Concept Videos
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Regulation of Food Intake
Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Incomplete Dominance
Epistasis Analysis
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

