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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Frontiers and opportunities in chemoenzymatic synthesis
Jonathan D Mortison1, David H Sherman
1Life Sciences Institute, Department of Chemistry and Department of Medicinal Chemistry, 210 Washtenaw Avenue, University of Michigan, Ann Arbor, Michigan 48109, USA.
The Journal of Organic Chemistry
|October 2, 2010
Summary
Natural product biosynthesis utilizes enzymes for complex chemical transformations. Chemoenzymatic synthesis harnesses these enzymes, offering powerful new methods for creating diverse molecules.
Area of Science:
- Biochemistry and Synthetic Chemistry
- Enzymology and Natural Product Synthesis
Background:
- Natural product biosynthetic pathways possess enzymes with diverse catalytic activities.
- These enzymes are crucial for constructing complex secondary metabolites.
Purpose of the Study:
- To highlight research efforts in harnessing biosynthetic enzymes.
- To showcase progress in chemoenzymatic synthesis for accessing chemical diversity.
Main Methods:
- Exploration of enzymes from various biosynthetic systems.
- Application of chemoenzymatic synthesis strategies.
Main Results:
- Demonstration of enzymes' broad chemical transformation capabilities.
- Successful application of chemoenzymatic synthesis in accessing novel chemical entities.
Conclusions:
- Chemoenzymatic synthesis is a powerful tool rivaling traditional synthetic chemistry.
- This approach opens new avenues for exploring and producing diverse natural products.
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