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Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
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Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Published on: December 19, 2020

Sequence-dependent interaction of β-peptides with membranes.

Jagannath Mondal1, Xiao Zhu, Qiang Cui

  • 1Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

The Journal of Physical Chemistry. B
|October 2, 2010
PubMed
Summary

Computer simulations reveal sequence-specific membrane interactions for antimicrobial beta-peptides. Peptide sequence, not global amphiphilicity, dictates membrane binding, suggesting rational design strategies for new antimicrobial agents.

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