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Updated: Jun 8, 2026
10:37
Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Hepatitis B reactivation and current clinical impact.
B Alvarez-Suárez1, J de-la-Revilla-Negro, B Ruiz-Antorán
1Servicio de Gastroenterología y Hepatología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Universidad Autónoma de Madrid, Spain.
Revista Espanola De Enfermedades Digestivas
|October 2, 2010
Summary
Hepatitis B virus (HBV) reactivation can occur in carriers or those with prior infection, especially during immunosuppressive therapy. Screening and antiviral prophylaxis are key preventive strategies for managing HBV reactivation risks.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Hepatitis B virus (HBV) reactivation involves increased viral replication in individuals with prior HBV infection or in inactive carriers.
- Reactivation can be spontaneous or triggered by immunomodulatory or immunosuppressive treatments, potentially leading to acute or severe hepatitis.
Purpose of the Study:
- To highlight the importance of preventing Hepatitis B virus reactivation.
- To emphasize the role of screening and antiviral prophylaxis in managing patients at risk.
Main Methods:
- Review of existing literature on HBV reactivation.
- Analysis of screening protocols and prophylactic antiviral therapies.
Main Results:
- HBV screening via serology is recommended for all patients undergoing immunosuppressive or chemotherapeutic treatments.
- Antiviral prophylaxis demonstrates effectiveness in preventing reactivation in inactive carriers and certain patients with prior HBV infection undergoing specific therapies.
Conclusions:
- Proactive screening for Hepatitis B virus is crucial for patients receiving immunosuppressive therapies.
- Antiviral prophylaxis is an effective strategy for preventing HBV reactivation in at-risk populations.
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