Related Experiment Video
Updated: Aug 19, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Abnormal low density lipoproteins composition in some chronic alcoholics: a possible mechanism
M Naruszewicz1, E Mirkiewicz, H Wehr
1Department of Pathothysiology, National Food and Nutrition Institute, Warsaw, Poland.
Abstract:
Decreased plasma low density lipoproteins (LDL) cholesterol and apolipoprotein B (apo B) levels are observed in heavy alcohol drinkers. LDL composition was determined in 16 alcohol addicts immediately after a period of alcohol abuse. Cholesterol to apo B ratio in the LDL fraction was significantly higher in the alcoholic group when compared with controls. In half of them the ratio exceeded 1.75. LDL subfractionation showed that in all subjects with atypically high LDL cholesterol to apolipoprotein B ratio, most of the LDL was in the form of a light subfraction. Acetylation in vitro showed that the heavy LDL subfraction was modified to a greater extent than the light subfraction. This suggests that the low apo B levels often observed after heavy drinking may arise from enhanced removal of the heavy LDL subfraction from the bloodstream.
Related Concept Videos
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Cholesterol: Significance and Regulation
Considering cholesterol and...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Atherosclerosis I: Introduction
Chronic Pancreatitis I: Introduction
Chronic Pancreatitis II: Pathophysiology

