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Updated: Jun 8, 2026
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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
Fifteen years' experience in thyroid surgery.
1Department of ENT/Head & Neck and Thyroid Surgery, Queen Elizabeth Hospital, University of Birmingham NHS Trust, The School of Clinical and Experimental Medicine, Institute of Biomedical Research, Birmingham, UK. john.watkinson@uhb.nhs.uk
Annals of the Royal College of Surgeons of England
|October 2, 2010
Summary
Thyroid disease management involves surgery and molecular investigations. TSH drives thyroid growth, while PTTG and PBF proto-oncogenes promote thyroid cancer by inducing tumors and affecting sodium iodide symporter function.
Area of Science:
- Endocrinology
- Molecular Biology
- Surgical Oncology
Background:
- Thyroid disease is prevalent, with thyroid cancer being less common.
- Standard investigations include blood tests, ultrasound, and fine needle aspiration cytology.
- Surgical options range from lobectomy to total thyroidectomy, with neck dissection for malignancy.
Purpose of the Study:
- To investigate mechanisms of thyroid growth (goitrogenesis) and carcinogenesis at a molecular level.
- To evaluate the role of pituitary tumour transforming gene (PTTG), PTTG binding factor (PBF), and sodium iodide symporter (NIS) in thyroid cell function.
Main Methods:
- Analysis of 1113 benign and 387 malignant thyroid disease cases.
- Surgical procedures included lobectomy, near-total, and total thyroidectomy.
- Investigation using 500 human thyroid cell primary cultures and three animal models.
Main Results:
- Thyroid-stimulating hormone (TSH) is the primary mediator of thyroid follicular cell growth.
- Overexpression of PTTG and PBF proto-oncogenes induces tumors in animal models.
- PTTG promotes human thyroid cell proliferation and represses NIS expression and function.
Conclusions:
- TSH is a key factor in thyroid growth.
- PTTG and PBF play significant roles in thyroid carcinogenesis.
- Understanding these molecular mechanisms can inform future thyroid disease research and treatment.
