Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modified-Release Drug Delivery Systems: Overview

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Oral Drug Delivery Systems: Continuous-Release Systems

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of drug solubility, polymer, and filler on drug release from modified-release matrix tablets in hydroethanolic media.

International journal of pharmaceutics·2026

Same author

Sonication-assisted emulsification: Analyzing different polymers in aqueous systems for microparticle preparation by the double emulsion technique.

Ultrasonics sonochemistry·2025

Same author

Control of encapsulation efficiency and morphology of poly(lactide-co-glycolide) microparticles with a diafiltration-driven solvent extraction process.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2024

Same author

Accelerated removal of solvent residuals from PLGA microparticles by alcohol vapor-assisted fluidized bed drying.

International journal of pharmaceutics·2024

Same author

Acceleration of Final Residual Solvent Extraction From Poly(lactide-co-glycolide) Microparticles.

Pharmaceutical research·2024

Same author

Porous PLGA microparticles prepared with nanosized/micronized sugar particles as porogens.

International journal of pharmaceutics·2024

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Modified release from hydroxypropyl methylcellulose compression-coated tablets.

Soravoot Rujivipat¹, Roland Bodmeier

¹College of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany.

International Journal of Pharmaceutics

|October 2, 2010

Summary

This summary is machine-generated.

Hydroxypropyl methylcellulose (HPMC) compression-coated tablets offer flexible drug release profiles, including sigmoidal and pulsatile patterns, adaptable for various drug solubilities and controlled by coating properties.

More Related Videos

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Related Experiment Videos

Last Updated: Jun 8, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Materials Science

Background:

Achieving flexible extended drug release profiles (sigmoidal, pulsatile, variable rates) is crucial for optimizing therapeutic outcomes.
Hydroxypropyl methylcellulose (HPMC) is a widely used polymer in pharmaceutical formulations for controlled release.

Purpose of the Study:

To develop and evaluate a hydroxypropyl methylcellulose (HPMC) compression-coated tablet system for flexible extended drug release.
To investigate the influence of drug solubility and HPMC properties on release profiles.
To explore methods for achieving specific release patterns like pulsatile release for various drug types.

Main Methods:

Formulation of HPMC compression-coated tablets with drugs of varying solubility (carbamazepine, acetaminophen, propranolol HCl, chlorpheniramine maleate).
Evaluation of drug release profiles, lag times, and release phases.
Modification of HPMC molecular weight, coating amount, and thickness.
Introduction of an enteric subcoating for specific release modifications.

Main Results:

HPMC compression-coating enabled distinct lag times followed by release phases determined by drug solubility.
Water-insoluble drugs showed pulsatile release post-erosion, while soluble drugs exhibited sigmoidal release via diffusion.
HPMC molecular weight significantly impacted lag time for insoluble drugs but not soluble ones.
Coating parameters (amount, thickness) and enteric subcoating allowed precise control over release rates and patterns.

Conclusions:

The HPMC compression-coated system provides a versatile platform for achieving diverse extended drug release profiles.
This single-unit delivery system demonstrates flexibility for a wide range of drugs with tunable release characteristics.
The study highlights the potential for tailored drug delivery through controlled erosion and diffusion mechanisms.