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A Rat Model of Compound Acne
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Published on: November 1, 2024

Hidradenitis suppurativa.

F William Danby1, Lynette J Margesson

  • 1Dartmouth Medical School, Hanover, NH, USA. billd860@gmail.com

Dermatologic Clinics
|October 2, 2010
PubMed
Summary
This summary is machine-generated.

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin condition. It begins with follicular occlusion in specific body areas, leading to inflammation and scarring.

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Last Updated: Jun 8, 2026

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03:10

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Published on: November 1, 2024

Area of Science:

  • Dermatology
  • Pathophysiology of skin disorders

Background:

  • Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
  • It affects intertriginous areas, including axillary, inguinal, and genital regions.
  • HS is also known as acne inversa or Verneuil disease.

Purpose of the Study:

  • To clarify the pathophysiology of hidradenitis suppurativa.
  • To discuss the proposed renaming of the condition to acne inversa.
  • To highlight the primary event in HS pathogenesis.

Main Methods:

  • Review of current understanding of HS pathogenesis.
  • Analysis of the initial event in HS development.
  • Comparison with acne vulgaris pathogenesis.

Main Results:

  • Follicular occlusion is identified as the primary event in HS.
  • Pathogenetic changes originate in the pilosebaceous follicular ducts.
  • This supports the proposed renaming to acne inversa.

Conclusions:

  • The term hidradenitis suppurativa is widely accepted despite being a misnomer.
  • Understanding follicular occlusion is key to HS pathophysiology.
  • The condition shares similarities with acne, supporting the acne inversa nomenclature.