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Updated: Jun 8, 2026

Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli
Published on: March 24, 2023
Plasmid-mediated quinolone resistance gene detected in Escherichia coli from cattle
Miranda Kirchner1, Heather Wearing, Christopher Teale
1Veterinary Laboratories Agency, Woodham, Lane, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom. m.kirchner@vla.defra.gsi.gov.uk
Abstract:
Fluoroquinolones resistance in bacteria can be due to chromosomal and plasmid-mediated mechanisms. Of growing concern is the acquisition of genes encoding quinolone resistance in combination with other resistance mechanisms such as extended-spectrum beta-lactamases. In this study we describe the identification of an isolate of Escherichia coli from cattle which carried qnrS1 in combination with a blaCTX-M gene, although they were not co-localised on the same plasmid. In addition, using a DNA array it was possible to identify several other antimicrobial resistance genes in this isolate. This is the first report of a qnr gene in E. coli from cattle in the UK and highlights the need for surveillance of these emerging resistance mechanisms.
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