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In vitro Reconstitution of the Active T. castaneum Telomerase
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Yeast telomerase protein Est3 is a novel type of GTPase

Olga Shubernetskaya1, Natalia Logvina, Yury Sharanov

  • 1Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119991, Russia.

Biochimie
|October 2, 2010
PubMed

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
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Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...
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