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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

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Related Experiment Video

Updated: Jun 8, 2026

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Published on: December 2, 2022

Report: prunes and liver function: a clinical trial.

Talat Ahmed¹, Halima Sadia, Aneela Khalid

¹Pharmacology & Therapeutics Section, Shifa College of Medicine, Islamabad, Pakistan. talatnishat@hotmail.com

Pakistan Journal of Pharmaceutical Sciences

|October 2, 2010

Summary

This summary is machine-generated.

Consuming prunes may benefit liver health. A study found that a lower dose of prunes significantly reduced key liver enzymes, suggesting a positive impact on liver function.

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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Area of Science:

Hepatology
Nutritional Science
Clinical Nutrition

Background:

Prunes (Prunus domestica) are traditionally used as a remedy for various ailments, including liver conditions.
Limited clinical evidence exists regarding the specific effects of prune consumption on liver function markers.

Purpose of the Study:

To investigate the impact of regular prune consumption on liver function in healthy volunteers.
To determine if different doses of prunes influence specific liver enzyme levels.

Main Methods:

A randomized clinical trial involving 166 healthy volunteers.
Participants were assigned to consume either a low dose (3 prunes) or high dose (6 prunes) of prune juice and fruit daily for 8 weeks, or a placebo (water).
Blood samples were analyzed at baseline and after 8 weeks to measure serum liver enzymes (ALT, AST, ALP) and bilirubin.

Main Results:

A significant reduction in serum alanine transaminase (ALT) was observed with the lower prune dose (p=0.048).
Serum alkaline phosphatase (ALP) also showed a significant decrease with the lower prune dose (p=0.017).
No significant changes were noted in serum aspartate transaminase (AST) or bilirubin levels across groups.

Conclusions:

Prune consumption, particularly at a lower dose, demonstrated a beneficial effect on specific liver enzymes.
These findings suggest that prunes may play a positive role in managing liver health and could be beneficial in cases of hepatic disease.
Further research is warranted to explore the clinical relevance and mechanisms behind prune's effects on liver function.