Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transforming growth factor-alpha: an oncodevelopmental growth factor.

D S Salomon1, N Kim, T Saeki

  • 1Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

Cancer Cells (Cold Spring Harbor, N.Y. : 1989)
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomised study of encorafenib, cetuximab, and FOLFIRI versus FOLFIRI with or without bevacizumab in BRAF V600E-mutant colorectal cancer: BREAKWATER Cohort 3.

Annals of oncology : official journal of the European Society for Medical Oncology·2026
Same author

<i>HER-2</i> gene alterations as biomarker in patients with metastatic colorectal cancer treated with FOLFIRI + cetuximab: findings from the CAPRI-2 GOIM study.

ESMO gastrointestinal oncology·2026
Same author

Clinical and translational results from the phase II ABACO trial evaluating the activity of cabozantinib in pretreated patients with metastatic colorectal cancer.

ESMO gastrointestinal oncology·2026
Same author

Off-label drug use in oncology: integrating molecular and genetic analysis in an academic center's real-world approach.

ESMO real world data and digital oncology·2026
Same author

Establishment of the Campania Oncology Network (Rete Oncologica Campana, ROC): a paradigm shift in oncological care and real world research in the Campania region.

ESMO real world data and digital oncology·2026
Same author

Managing adverse events in patients with metastatic colorectal cancer receiving trifluridine/tipiracil in combination with bevacizumab.

ESMO gastrointestinal oncology·2026
Same journal

Epithelial cell plasticity in neoplasia.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

Uptake of low-density lipoprotein by malignant cells--possible therapeutic applications.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

Some thoughts on the cytolytic mechanism of natural killer lymphocytes.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

JE/MCP-1: an early-response gene encodes a monocyte-specific cytokine.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

A role for cholinesterases in tumorigenesis?

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

The soluble interleukin-2 receptor as a marker for human neoplasia and immune status.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
See all related articles

Transforming growth factor-alpha (TGF-alpha), a peptide related to epidermal growth factor (EGF), is biologically active in its precursor and peptide forms. This growth factor plays roles in development and adult tissues, potentially acting in autocrine or paracrine signaling.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Transforming growth factor-alpha (TGF-alpha) is a mitogenic peptide structurally related to epidermal growth factor (EGF).
  • TGF-alpha is synthesized as a glycosylated, membrane-associated precursor.
  • Both the precursor and mature TGF-alpha peptide exhibit biological activity.

Purpose of the Study:

  • To describe the structural and functional characteristics of TGF-alpha.
  • To investigate the biological activity of TGF-alpha and its precursor.
  • To explore the role of TGF-alpha in cellular growth and development.

Main Methods:

  • Analysis of TGF-alpha structure and synthesis.
  • Assessment of TGF-alpha biological activity in various systems.

Related Experiment Videos

  • Examination of TGF-alpha and EGF receptor coexpression in tumors.

    • Main Results:

    • TGF-alpha is a 50-amino-acid peptide derived from a larger precursor.
    • Both TGF-alpha forms are biologically active and can promote cell transformation.
    • TGF-alpha binds to and activates the EGF receptor.
    • Coexpression of TGF-alpha and EGF receptor suggests autocrine/paracrine roles in tumors.
    • TGF-alpha expression patterns indicate involvement in development and adult tissue functions.

    Conclusions:

    • TGF-alpha is a significant growth factor with roles in cell proliferation and potentially in tumorigenesis.
    • The interaction between TGF-alpha and the EGF receptor is crucial for its function.
    • TGF-alpha's diverse expression suggests broad physiological importance.