Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects

Area of Science:

• Cardiovascular Research
• Molecular Biology
• Medical Science

Background:

• Vascular endothelial growth factor (VEGF) discovery spurred interest in therapeutic angiogenesis for ischemic conditions.
• Angiogenesis is implicated in the development and consequences of atherosclerotic disease.
• Conflicting views on angiogenesis roles stem from preclinical rodent models.

Purpose of the Study:

• To review therapeutic angiogenesis in light of recent scientific advances.
• To discuss clinical evidence for pro-angiogenic and anti-angiogenic treatments.
• To consider future challenges and prospects for therapeutic angiogenesis.

Main Methods:

• Review of preclinical data from rodent models.
• Analysis of results from clinical trials of pro- and anti-angiogenic therapies.
• Synthesis of recent scientific advances and clinical evidence.

Main Results:

• Preclinical data from rodent models provided initial insights.
• Clinical trials have yielded new understanding of VEGF's impact in humans.
• Evidence suggests complex roles for angiogenesis in cardiovascular health and disease.

Conclusions:

• Therapeutic angiogenesis requires careful consideration of its dual roles.
• Recent clinical evidence refines our understanding of VEGF-based therapies.
• Future research should address challenges and explore prospects for angiogenesis treatments.