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Dapsone versus corticosteroids in lichen planus.

A Chopra¹, R R Mittal, B Kaur

¹Department of Skin and VD,Government Medical College /Rajindra Hospital, Patiala(Punjab), India.

Indian Journal of Dermatology, Venereology and Leprology

|October 2, 2010

Summary

This summary is machine-generated.

Oral dapsone combined with chlorpheniramine maleate and coconut oil demonstrated superior efficacy for treating Lichen Planus (LP) compared to local corticosteroids. This dapsone regimen showed an 18% higher total efficacy rate.

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Area of Science:

Dermatology
Pharmacology

Background:

Lichen Planus (LP) is an inflammatory condition affecting skin and mucous membranes.
Current treatments for LP vary in efficacy and potential side effects.

Purpose of the Study:

To evaluate the therapeutic effectiveness of oral dapsone in managing Lichen Planus.
To compare the efficacy of dapsone-based treatment with a regimen of local corticosteroids.

Main Methods:

A comparative study involving 75 patients diagnosed with Lichen Planus.
Patients were divided into two groups: Regimen 1 (R1) received local corticosteroids and chlorpheniramine maleate; Regimen 2 (R2) received oral dapsone, chlorpheniramine maleate, and topical coconut oil.

Main Results:

Regimen 2 (R2), incorporating oral dapsone, showed a significantly higher total efficacy.
The dapsone-containing regimen (R2) was found to be 18% more effective than Regimen 1 (R1).

Conclusions:

Oral dapsone presents a promising therapeutic option for Lichen Planus.
The combination of dapsone, chlorpheniramine maleate, and coconut oil offers enhanced treatment outcomes for LP patients.