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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Jun 8, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Amyloid imaging using high-field magnetic resonance.

Tomone Amatsubo¹, Daijiro Yanagisawa, Shigehiro Morikawa

¹Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan.

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine

|October 2, 2010

Summary

Early detection of Alzheimer's disease (AD) relies on identifying amyloid plaques. This review highlights advances in magnetic resonance (MR) imaging techniques for visualizing these early AD pathological changes.

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Area of Science:

Neuroimaging
Biomarkers
Alzheimer's Disease Research

Background:

Senile plaques and amyloid-beta (Aβ) peptide deposition are the earliest pathological hallmarks of Alzheimer's disease (AD).
Early detection of these plaques is crucial for diagnosing AD.
Current diagnostic methods include positron emission tomography (PET) and magnetic resonance (MR) imaging.

Purpose of the Study:

To review recent advancements in amyloid plaque detection using MR imaging.
To present novel ligands developed for MR imaging of amyloid plaques.
To discuss the role of MR imaging in early AD diagnosis.

Main Methods:

Review of current literature on amyloid imaging techniques.
Focus on MR imaging ligands and probes.
Inclusion of specific research studies on MR-based amyloid detection.

Main Results:

Limited development of specific ligands for MR imaging compared to PET.
Emerging progress in MR imaging probes for amyloid plaque visualization.
Potential for MR imaging as a noninvasive tool for early AD diagnosis.

Conclusions:

MR imaging offers a promising noninvasive approach for detecting early Alzheimer's disease pathology.
Further development of MR imaging ligands is essential for improved sensitivity and specificity.
Advancements in MR imaging hold significant potential for early AD diagnosis and monitoring.