Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dihybrid Crosses01:18

Dihybrid Crosses

Overview
Genetics of Speciation02:16

Genetics of Speciation

Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.The genetics of speciation involves the different traits or isolating mechanisms preventing gene exchange, leading to reproductive isolation. Reproductive isolation can be due to reproductive barriers that have effects either before or after the formation of a zygote. Pre-zygotic mechanisms prevent fertilization from occurring, and post-zygotic mechanisms...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Understanding Species and Reproductive Barriers01:17

Understanding Species and Reproductive Barriers

A species is a group of organisms that interbreed and produce fertile offspring. Typically, individuals of the same species appear similar and share common characteristics due to their highly similar genomes. However, not all organisms that look alike are members of the same species. Various mechanisms keep most species discrete. While some mechanisms prevent reproductive behavior and fertilization (pre-zygotic isolation), others prevent the production of fertile offspring after mating has...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Gene Flow02:39

Gene Flow

Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TGFβ activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver disease.

Molecular metabolism·2026
Same author

Cross-species rescue reveals sequence requirements for a rapidly evolving intrinsically disordered region.

PLoS biology·2025
Same author

The regulatory mechanisms controlling meiotic cross-over patterning in plants.

Biochemical Society transactions·2025
Same author

Mex3a-dependent post-transcriptional silencing ensures olfactory receptor diversity and axon guidance specificity.

Cell reports·2025
Same author

The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity.

Nature aging·2025
Same author

ANAPHASE-PROMOTING COMPLEX/CYCLOSOME coactivators maintain AURORA 1 kinase homeostasis during meiotic chromosome segregation.

The Plant cell·2025

Related Experiment Video

Updated: Jun 8, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Genetic interference: don't stand so close to me.

Luke E Berchowitz1, Gregory P Copenhaver

  • 1Department of Biology and the Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3280, USA.

Current Genomics
|October 2, 2010
PubMed
Summary
This summary is machine-generated.

Genetic interference ensures proper chromosome segregation during meiosis, preventing disorders like Down syndrome. This review explores the mechanisms and challenges in understanding this crucial biological phenomenon.

Keywords:
Double-strand breakMeiosisPch2.Rec8chromosome Spo11crossoverrecombinationsynaptonemal complex

More Related Videos

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Related Experiment Videos

Last Updated: Jun 8, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Area of Science:

  • Genetics
  • Cell Biology
  • Developmental Biology

Background:

  • Meiosis is essential for sexual reproduction, involving chromosome condensation, pairing, crossing-over, and disjunction.
  • Proper regulation of meiotic crossovers is critical for accurate chromosome segregation.
  • Aberrant crossover distribution can lead to genetic disorders such as Down syndrome and Edwards syndrome.

Purpose of the Study:

  • To review the current understanding of genetic interference in meiosis.
  • To highlight the progress and remaining challenges in elucidating the mechanisms of interference.
  • To synthesize findings across diverse organisms, from yeasts to humans.

Main Methods:

  • Review of existing literature on meiotic recombination and interference.
  • Analysis of data from various model organisms.
  • Synthesis of historical and recent research findings.

Main Results:

  • Genetic interference leads to non-random, more even spacing of meiotic crossovers.
  • This phenomenon is conserved across a wide range of sexually reproducing organisms.
  • Despite extensive study, the precise molecular mechanisms underlying interference remain largely unknown.

Conclusions:

  • Understanding genetic interference is key to preventing meiotic errors and associated genetic disorders.
  • Further research is needed to unravel the complex molecular mechanisms governing crossover distribution.
  • Continued investigation across diverse species will advance our knowledge of this fundamental biological process.