Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The monoclonals: What have we learned and where are we going?

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Pragmatic Strategies for Reducing Variability and Risk in Food Oral Immunotherapy.

Clinical reviews in allergy & immunology·2026
Same author

Pirfenidone and its Derivative: Novel Bronchodilators and Leukocyte Airway Inflammation Inhibitors.

American journal of respiratory cell and molecular biology·2026
Same author

No evidence of a differential treatment effect with omalizumab versus placebo across baseline IgE level and BMI subgroups in patients with chronic spontaneous urticaria.

The journal of allergy and clinical immunology. In practice·2026
Same author

Dupilumab in Patients With Chronic Spontaneous Urticaria: Phase 3 LIBERTY-CSU CUPID Randomized Clinical Trials.

JAMA dermatology·2026
Same author

Efficacy of Epinephrine Nasal Spray in the Treatment of Urticaria.

The journal of allergy and clinical immunology. In practice·2026
Same journal

Allergenic Characterization of Parvalbumin, Tric l 1, From Atlantic cutlassfish, <i>Trichiurus lepturus</i>.

Allergy, asthma & immunology research·2026
Same journal

Increased Levels of Serum Eosinophil-Derived Neurotoxin in Patients With Chronic Spontaneous Urticaria.

Allergy, asthma & immunology research·2026
Same journal

Serum Neuropeptides in Chronic Spontaneous Urticaria: Associations With Disease Activity and Clinical Phenotypes.

Allergy, asthma & immunology research·2026
Same journal

Real-World Efficacy and Safety of Upadacitinib in Korean Patients With Atopic Dermatitis.

Allergy, asthma & immunology research·2026
Same journal

Prevalence of Immediate-Type Food Allergy and Food-Induced Anaphylaxis in Korean Schoolchildren.

Allergy, asthma & immunology research·2026
Same journal

Efficacy and Adherence of Combined Fluticasone Propionate and Azelastine Nasal Spray Versus Fluticasone Propionate Alone in Pediatric Allergic Rhinitis.

Allergy, asthma & immunology research·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Immunomodulators for asthma.

Vesselin V Dimov1, Thomas B Casale

  • 1Division of Allergy & Immunology, Department of Medicine, Creighton University, Omaha, NE, USA.

Allergy, Asthma & Immunology Research
|October 2, 2010
PubMed
Summary
This summary is machine-generated.

Novel immunomodulators targeting allergic diseases show promise in human trials, despite disparities between mouse models and human asthma. This review focuses on treatments currently in clinical development for asthma and related conditions.

Keywords:
Asthmacytokinesimmunomodulatorstreatment

More Related Videos

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Related Experiment Videos

Last Updated: Jun 8, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Area of Science:

  • Immunology
  • Allergy and Asthma Research

Background:

  • Understanding the molecular mechanisms of allergic disorders is crucial for developing new treatments.
  • Asthma and allergic diseases involve complex immunological pathways.

Purpose of the Study:

  • To review the pathogenesis of asthma and allergic diseases.
  • To discuss the rationale for using immunomodulators in treating these conditions.
  • To examine the therapeutic effects of immunomodulators currently in human clinical trials.

Main Methods:

  • Literature review of immunomodulators for allergic disorders.
  • Focus on agents in human clinical trials, excluding pre-clinical developments.
  • Analysis of therapeutic effects and clinical trial outcomes.

Main Results:

  • Several immunomodulators show promise in pre-clinical studies but have not translated to significant human clinical benefits.
  • Discrepancies exist between results from mouse models and human asthma clinical trials.
  • The review highlights immunomodulators progressing through human clinical evaluation.

Conclusions:

  • Immunomodulators represent a key area for novel therapeutic approaches in allergic diseases.
  • Clinical translation of pre-clinical findings remains a challenge.
  • Further research into human clinical trials is essential for effective treatment development.