Related Experiment Video
Updated: Jun 8, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Passive smoking and the development of cardiovascular disease in children: a systematic review
Giorgos S Metsios1, Andreas D Flouris, Manuela Angioi
1School of Sport, Performing Arts and Leisure, University of Wolverhampton, Walsall, West Midlands WS1 3BD, UK.
Insights
Secondhand smoke exposure in children is linked to factors that can lead to cardiovascular disease (CVD). This systematic review found it may negatively impact cholesterol levels and blood vessel function in kids.
Area of Science:
- Pediatric Health
- Environmental Health
- Cardiovascular Disease Research
Background:
- Children's developing physiological systems may be particularly vulnerable to environmental toxins.
- Passive smoking (secondhand smoke exposure) is a recognized public health concern.
- Existing research suggests potential links between passive smoking and adverse health outcomes in children.
Purpose of the Study:
- To systematically investigate the association between passive smoking and factors influencing cardiovascular disease (CVD) development in children.
- To synthesize evidence on how secondhand smoke affects pediatric cardiovascular health indicators.
- To identify specific cardiovascular risk factors potentially exacerbated by passive smoking in pediatric populations.
Main Methods:
- Systematic literature search across multiple databases including Medline, Cochrane Library, CINAHL, Google Scholar, and EMBASE.
- Inclusion of relevant articles from major governmental reports (Surgeon General's report, California EPA report).
- Analysis of 42 identified articles, comprising 30 reviews and 12 observational studies.
Main Results:
- Passive smoking is associated with unfavorable high-density lipoprotein (HDL) cholesterol levels in children.
- Evidence suggests passive smoking contributes to deteriorated vascular function in pediatric populations.
- The findings indicate a potential link between secondhand smoke exposure and early cardiovascular risk factors in children.
Conclusions:
- Passive smoking exposure may negatively impact key indicators of cardiovascular health in children.
- Deterioration in HDL levels and vascular function are potential consequences of secondhand smoke exposure in youth.
- Further research and public health interventions are warranted to mitigate the cardiovascular risks of passive smoking in children.
Abstract:
Passive smoking may be implicated in the development of cardiovascular disease (CVD) in children because of their partially developed physiological systems. The aim of the present systematic paper is to investigate whether passive smoking is associated with factors that influence the development of CVD in children. Data sources included Medline, Cochrane Library, Cumulative Index to Nursing & Allied Health (CINAHL) research database, Google Scholar, Excerpta Medica database (EMBASE), the 2006 Office of the Surgeon General's report, and the 2005 report from the California Environmental Protection Agency. We identified a total of 42 relevant articles (i.e., 30 reviews and 12 observational). Results revealed that passive smoking may be implicated in deteriorating cardiovascular status in children in terms of unfavorable high-density lipoprotein levels and deteriorated vascular function.
Related Concept Videos
Chronic Obstructive Pulmonary Disease I: Introduction
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Coronary Artery Disease I: Introduction

