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Related Concept Videos

Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Double thyroid ectopia (with incidental papillary thyroid microcarcinoma) (2010: 8b).

Alexandra Borges1, Mariluz Martins, Saudade André

  • 1Department of Radiology, Instituto Português de Oncologia de Francisco Gentil-Centro de Lisboa, Rua Prof. Lima Basto, 1093, Lisbon, Portugal. borgalexandra@gmail.com

European Radiology
|October 2, 2010
PubMed
Summary

A man with a neck mass had double thyroid ectopia, with ectopic thyroid tissue found in his submandibular space and tongue base. Pathology revealed an ectopic thyroid goiter and incidental papillary microcarcinoma.

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Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Head and Neck Surgery

Background:

  • Thyroid ectopia is a rare congenital condition where thyroid tissue is found outside its normal location.
  • Ectopic thyroid tissue can present as a neck mass, often in the midline or lateral neck.
  • Diagnosis typically involves imaging and pathological examination.

Observation:

  • A 45-year-old male presented with a slow-growing left submandibular mass.
  • Imaging revealed an absent orthotopic thyroid gland and heterogeneous masses with cystic components and calcifications in the left submandibular and tongue base regions.
  • These findings were consistent with double thyroid ectopia, originating from central and lateral thyroid anlages.

Findings:

  • Pathology confirmed an ectopic thyroid goiter in the left submandibular space.
  • An incidental papillary microcarcinoma was discovered within the ectopic thyroid tissue.
  • Scintigraphy confirmed the presence of ectopic thyroid tissue in the left tongue base.

Implications:

  • This case highlights the importance of considering thyroid ectopia in the differential diagnosis of neck masses, even in adults.
  • The presence of papillary microcarcinoma in ectopic thyroid tissue underscores the need for thorough pathological evaluation.
  • Understanding the embryological origins of thyroid ectopia is crucial for accurate diagnosis and management.